Neurology Updates

The Lancet Neurology

The clinical relevance of multiple sclerosis genetics: from susceptibility to disease severity and progression

Large-scale genome-wide association studies have identified hundreds of multiple sclerosisrisk loci, most of which implicate immune pathways and establish multiple sclerosisas a highly polygenic, immune-mediated disease. These findings help explain why…

Nature

Sustained antidepressant-like effects of psychedelics through 5-HT2AR–β-arrestin signaling

Nature Neuroscience - This study shows that the sustained antidepressant-like effect of psychedelics is driven by 5-HT2A receptor–β-arrestin signaling. Repeated low-dose LSD preserves...

Nature

Identification of candidate markers for the isolation of neuron-specific extracellular vesicles

Nature Neuroscience - The authors developed methods to identify extracellular vesicles (EVs) in the blood that come from the brain by capturing EV surface proteins. This could be used in the future...

Jamanetwork

Risk of Inflammatory Bowel Disease After Anti-CD20 Treatment in Multiple Sclerosis

This cohort study investigates if anti-CD20 treatment is associated with an increase in the risk of inflammatory bowel disease in individuals with multiple sclerosis (MS).

Nature

Behavioral genomics identifies Creld1 as a cross-modal regulator of somatosensation

Nature Neuroscience - Jiang et al. developed a robust postnatal knockout platform for somatosensory genomics and behavioral screening, identifying Creld1 as a cross-modal regulator of...

Nature

Network geometry shapes the transformation of task representations across the human cortex

Nature Neuroscience - The dimensionality of intrinsic brain connectivity systematically shapes how task representations compress and expand across the cortex, and activity flow modeling shows the...

Nature

SIK3 controls synaptic localization of NMDA receptors by phosphorylating GluN1

Nature Neuroscience - SIK3 kinase controls synaptic NMDA receptor recruitment by phosphorylating GluN1 at a single site. Loss or inhibition of SIK3 markedly reduces synaptic NMDARs, while a...

Nature

A corticohypothalamic circuit that mediates maternal awakening to pup cries

Nature Neuroscience - Tang, Wu et al. identify a brain circuit that enables mother mice to wake selectively to pup cries. Motherhood strengthens this pathway through increased dopamine receptor D1...

Nature

Early lineage divergence segregates sensory and motor-associative identities in the thalamus

Nature Neuroscience - Sensory and motor-associative identities in the thalamus arise from two early-diverging lineages, with sensory neurons progressing through shared intermediate states,...

Nature

Dysregulated cholesterol trafficking through ABCA1 drives neurodegeneration in Parkinson’s disease

Nature Neuroscience - This study identifies ABCA1 as a driver of dysregulated cholesterol trafficking in Parkinson’s disease, showing that reducing ABCA1 in astrocytes and neurons decreases...

Jamanetwork

The Patient I Could Not Save

This essay describes the author’s experience with severe postpartum anxiety and depression, suicidal ideation, and her time on an inpatient psychiatry unit.

Jamanetwork

Vascular Risk Factors and Late-Onset Epilepsy

This pooled analysis of 6 US cohorts identifies vascular risk factors associated with incident late-onset epilepsy in older adults.

Nature

An amygdala-mediated simulation-to-decision cascade aligns interbrain dynamics to solve social dilemmas

Nature Neuroscience - Using simultaneous intracranial recordings from interacting human brains, Ma et al. show that mutual cooperation emerges when amygdala activity aligns across partners and...

Nature

Spatiotemporal remodeling in habenula marks the onset of depression-related phenotypes

Nature Neuroscience - Molina et al. show in chronically stressed mice that neuronal and transcriptional adaptations in the habenula coincide with the onset of depressive phenotype, guiding...

Nature

Periventricular gradient pathology is linked to ependymal reactivity and cell adhesion disruption in multiple sclerosis

Nature Neuroscience - This study identifies ependymal dysfunction as a mechanism linking inflammatory cerebrospinal fluid to increased ventricular permeability and periventricular pathology in...

Nature

Spatiotemporal AI-based modeling of gene regulation and variant effects in the developing human brain using Seal

Nature Neuroscience - Seal is an artificial intelligence framework that predicts the effects of regulatory variants in 802 brain cell states, revealing spatiotemporal gene regulation and...

Nature

An aging-sensitive secreted phospholipase confers neuroprotection and cognitive resilience

Nature Neuroscience - This study identifies a secreted phospholipase in the hippocampal dentate gyrus that mediates an aging-sensitive compensatory mechanism promoting cognitive resilience and...

Nature

A half-center oscillator regulates sleep pressure

Nature Neuroscience - Hasenhuetl et al. show that neurons innervating the dorsal fan-shaped body of Drosophila form a half-center oscillator, a circuit motif typically found in central pattern...

Nature

5-HT2A receptors in layer 5 pyramidal neurons mediate the neuroplastic but not the hallucinogenic effects of psilocybin

Nature Neuroscience - Psilocybin promotes and stabilizes new connections between neurons in the mouse cerebral cortex, especially after stress. Baker et al. show that 5-HT2A receptor signaling in...

Nature

Symmetries and continuous attractors in disordered neural circuits

Nature Neuroscience - Head-direction cells are far more disorderly than classical continuous-attractor models allow. Clark et al. show that this disorder is nevertheless compatible with these...